MOTS-c: The Mitochondrial Regulator

The Onyx Biolabs MOTS-C Peptide is a premium research compound (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a specialized mitochondrial-derived peptide (MDP) that has garnered significant attention in the field of metabolic research. Unlike most peptides which are encoded by the nuclear genome, MOTS-c is encoded within the DNA of the mitochondria itself.

This unique origin allows it to act as a potent signaling molecule, regulating metabolic homeostasis and cellular energy communication. It is frequently referred to in literature as an “exercise mimetic” due to its ability to replicate the cellular benefits of physical exertion without muscular contraction.

About MOTS-C Peptide

Mechanism of Action: The AMPK Pathway Primary research focuses on the ability of MOTS-C Peptide to target the folate-methionine cycle and activate the AMPK (AMP-activated protein kinase) pathway.

• Metabolic Flexibility: By stimulating AMPK, MOTS-C Peptide is hypothesized to enhance glucose uptake in skeletal muscle and improve insulin sensitivity.

• Cellular Energy: It plays a critical role in mitochondrial biogenesis, potentially improving the efficiency of energy production at the cellular level.

• Fat Oxidation: Studies have observed its potential to prevent diet-induced obesity by increasing fat utilization (lipolysis) and promoting the browning of adipose tissue.

Research Applications & Storage This peptide is supplied as a lyophilized white powder to ensure stability during transport. For research protocols, it must be reconstituted with Bacteriostatic Water to maintain a sterile environment. Once reconstituted, the solution is sensitive to degradation and should be stored at 2-8°C away from direct light.

References

1. Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces diet-induced obesity. Cell Metabolism. 2015.

2. Kim KH, et al. Mitochondrial-derived peptides: A novel perspective on metabolic regulation. Endocrinology & Metabolism. 2017.

3. Reynolds, J. MOTS-c as an Exercise Mimetic and its Role in Skeletal Muscle. Journal of Applied Physiology. 2021.